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| I | Sporting Braga | - | Shakhtar Donetsk | 1:2 (0:1) | ||
| V | Shakhtar Donetsk | - | Sporting Braga | 4:0 (2:0) | ||
| I: 07.04.2016 21:05 | V: 14.04.2016 21:05 | Campeones: Shakhtar Donetsk | ||||
| I | Villarreal | - | Sparta Praga | 2:1 (1:1) | ||
| V | Sparta Praga | - | Villarreal | 2:4 (0:3) | ||
| I: 07.04.2016 21:05 | V: 14.04.2016 21:05 | Campeones: Villarreal | ||||
| I | Athletic | - | Sevilla | 1:2 (0:0) | ||
| V | Sevilla | - | Athletic | 5:4 (0:0, 1:2, 1:2) pn. | ||
| I: 07.04.2016 21:05 | V: 14.04.2016 21:05 | Campeones: Sevilla | ||||
| I | Borussia Dortmund | - | Liverpool | 1:1 (0:1) | ||
| V | Liverpool | - | Borussia Dortmund | 4:3 (0:2) | ||
| I: 07.04.2016 21:05 | V: 14.04.2016 21:05 | Campeones: Liverpool | ||||
