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| I | Standard Liège | - | Colonia | 0:0 (0:0) | ||
| V | Colonia | - | Standard Liège | 3:2 (1:1) | ||
| I: 04.03.1981 | V: 18.03.1981 | Campeones: Colonia | ||||
| I | AZ '67 Alkmaar | - | Sporting Lokeren | 2:0 (2:0) | ||
| V | Sporting Lokeren | - | AZ '67 Alkmaar | 1:0 (1:0) | ||
| I: 04.03.1981 | V: 18.03.1981 | Campeones: AZ '67 Alkmaar | ||||
| I | Saint-Étienne | - | Ipswich Town | 1:4 (1:1) | ||
| V | Ipswich Town | - | Saint-Étienne | 3:1 (0:0) | ||
| I: 04.03.1981 | V: 18.03.1981 | Campeones: Ipswich Town | ||||
| I | Grasshopper Club Zürich | - | FC Sochaux | 0:0 (0:0) | ||
| V | FC Sochaux | - | Grasshopper Club Zürich | 2:1 (1:1) | ||
| I: 04.03.1981 | V: 18.03.1981 | Campeones: FC Sochaux | ||||
