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| I | Partizan | - | CSKA Moscú | 1:1 (0:1) | ||
| V | CSKA Moscú | - | Partizan | 2:0 (0:0) | ||
| I: 10.03.2005 17:00 | V: 17.03.2005 18:30 | Campeones: CSKA Moscú | ||||
| I | Olympiacos | - | Newcastle United | 1:3 (1:2) | ||
| V | Newcastle United | - | Olympiacos | 4:0 (2:0) | ||
| I: 10.03.2005 18:00 | V: 16.03.2005 20:45 | Campeones: Newcastle United | ||||
| I | Shakhtar Donetsk | - | AZ Alkmaar | 1:3 (1:1) | ||
| V | AZ Alkmaar | - | Shakhtar Donetsk | 2:1 (1:0) | ||
| I: 10.03.2005 18:00 | V: 16.03.2005 20:30 | Campeones: AZ Alkmaar | ||||
| I | Austria Wien | - | Zaragoza | 1:1 (1:0) | ||
| V | Zaragoza | - | Austria Wien | 2:2 (0:2) | ||
| I: 10.03.2005 19:30 | V: 17.03.2005 20:45 | Campeones: Austria Wien | ||||
| I | Lille | - | AJ Auxerre | 0:1 (0:1) | ||
| V | AJ Auxerre | - | Lille | 0:0 (0:0) | ||
| I: 10.03.2005 20:30 | V: 17.03.2005 20:45 | Campeones: AJ Auxerre | ||||
| I | Middlesbrough | - | Sporting CP | 2:3 (0:0) | ||
| V | Sporting CP | - | Middlesbrough | 1:0 (0:0) | ||
| I: 10.03.2005 21:10 | V: 17.03.2005 20:45 | Campeones: Sporting CP | ||||
| I | Sevilla | - | Parma FC | 0:0 (0:0) | ||
| V | Parma FC | - | Sevilla | 1:0 (1:0) | ||
| I: 10.03.2005 21:30 | V: 17.03.2005 20:45 | Campeones: Parma FC | ||||
| I | FC Steaua Bucureşti | - | Villarreal | 0:0 (0:0) | ||
| V | Villarreal | - | FC Steaua Bucureşti | 2:0 (1:0) | ||
| I: 16.03.2005 19:00 | V: 20.03.2005 20:00 | Campeones: Villarreal | ||||
