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| I | Rapid Bucureşti | - | Hamburgo | 2:0 (1:0) | ||
| V | Hamburgo | - | Rapid Bucureşti | 3:1 (2:0) | ||
| I: 09.03.2006 16:00 | V: 15.03.2006 19:00 | Campeones: Rapid Bucureşti | ||||
| I | FC Steaua Bucureşti | - | Betis | 0:0 (0:0) | ||
| V | Betis | - | FC Steaua Bucureşti | 0:3 (0:0) | ||
| I: 09.03.2006 18:00 | V: 16.03.2006 21:30 | Campeones: FC Steaua Bucureşti | ||||
| I | Palermo | - | Schalke | 1:0 (1:0) | ||
| V | Schalke | - | Palermo | 3:0 (1:0) | ||
| I: 09.03.2006 18:00 | V: 16.03.2006 20:30 | Campeones: Schalke | ||||
| I | Lille | - | Sevilla | 1:0 (1:0) | ||
| V | Sevilla | - | Lille | 2:0 (2:0) | ||
| I: 09.03.2006 19:00 | V: 15.03.2006 21:00 | Campeones: Sevilla | ||||
| I | Basilea | - | RC Strasbourg | 2:0 (1:0) | ||
| V | RC Strasbourg | - | Basilea | 2:2 (1:2) | ||
| I: 09.03.2006 20:15 | V: 16.03.2006 18:00 | Campeones: Basilea | ||||
| I | Marsella | - | Zenit | 0:1 (0:0) | ||
| V | Zenit | - | Marsella | 1:1 (0:0) | ||
| I: 09.03.2006 20:45 | V: 16.03.2006 17:00 | Campeones: Zenit | ||||
| I | Udinese | - | Levski Sofia | 0:0 (0:0) | ||
| V | Levski Sofia | - | Udinese | 2:1 (0:1) | ||
| I: 09.03.2006 20:45 | V: 16.03.2006 17:30 | Campeones: Levski Sofia | ||||
| I | Middlesbrough | - | Roma | 1:0 (1:0) | ||
| V | Roma | - | Middlesbrough | 2:1 (1:1) | ||
| I: 09.03.2006 21:00 | V: 15.03.2006 21:00 | Campeones: Middlesbrough | ||||
