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| I | Feyenoord | - | Slavia Praga | 3:3 (1:1) | ||
| V | Slavia Praga | - | Feyenoord | 1:3 (1:1) | ||
| I: 07.04.2022 18:45 | V: 14.04.2022 21:00 | Campeones: Feyenoord | ||||
| I | FK Bodø/Glimt | - | Roma | 2:1 (0:1) | ||
| V | Roma | - | FK Bodø/Glimt | 4:0 (3:0) | ||
| I: 07.04.2022 21:00 | V: 14.04.2022 21:00 | Campeones: Roma | ||||
| I | Marsella | - | PAOK Saloniki | 2:1 (2:0) | ||
| V | PAOK Saloniki | - | Marsella | 0:1 (0:1) | ||
| I: 07.04.2022 21:00 | V: 14.04.2022 21:00 | Campeones: Marsella | ||||
| I | Leicester City | - | PSV | 0:0 (0:0) | ||
| V | PSV | - | Leicester City | 1:2 (1:0) | ||
| I: 07.04.2022 21:00 | V: 14.04.2022 18:45 | Campeones: Leicester City | ||||
